Category Archives: Fillers

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Injectable use on the rise as a cheaper alternative to cosmetic surgery

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A good visit to your plastic surgeon to do some reasonable botox, or fillers is easy. Not something to be afraid of and more people are doing it. Good results are often seen, but on the other hand remember that you can only get so much, o…nly go so far with “minimal” treatments. Don’t expect great results with minimal invasive treatments of any kind. To get the best results, state of the art techniques are needed and these need some down time, have risks, cost money.
 
 

Injectable use on the rise as a cheaper alternative to cosmetic surgery

Article from The Chicago Tribune
By Ed Finkel, Special to the Tribune

July 20, 2011

 
Demand for minimally invasive cosmetic procedures showed a three-digit increase over the last decade, with Botox leading the way for those seeking to look younger or better.

As of last month, would-be patients can consider a new product that uses their own collagen cells, which are multiplied in a lab to create an injectable substance that smoothes out facial features. Injections typically cost a fraction of surgery and require much less recuperation time.

“It’s taking hold. People are doing (injections) a lot more frequently,” said John Bull, a plastic surgeon in Naperville. “People that are looking for a modest improvement with less down time and no scars typically want to have this done. The best candidates are people with early signs of aging and volume loss.”

Laurette Agee, 51, who is general manager of a McDonald’s in Aurora, was a patient of Bull’s. More than four years after losing her husband of 26 years, Agee was ready to come out of her shell but noticed the aging process taking hold.

She did not warm to the idea of plastic surgery, so starting in February she began receiving different types of injections in her cheeks, lips and along the sides of her nostrils.

“I catch men looking at me now in a different perspective. It makes me feel very good,” Agee said. “At my son’s wrestling meets, other moms were like, ‘Did you have something done, Laurette? You look so good.’ I have no shame in saying, ‘I did this, and this, and this.’”

In the last decade, minimally invasive procedures have skyrocketed in popularity, from 5.5 million performed in 2000 to 11.6 million in 2010 — a 110 percent increase, according to the American Society of Plastic Surgeons. The best-known and most commonly used, Botox, jumped 584 percent.

Cosmetic surgical procedures were done 18 percent less often in 2010 than in 2000, with considerably larger drops in facelifts (65 percent), forehead lifts (57 percent), eyelid surgery (36 percent), chin augmentation (55 percent) and nose reshaping (35 percent), the society reports.

The new product, called laViv and approved by the Federal Drug Administration in late June, is what Chicago plastic surgeon Julius Few describes as “another tool in our chest.” It will take awhile to reach market and will be more expensive than other injectables, at least initially, Few said.

“It’s not going to be one of these things where people are going to put down their other options like Botox overnight,” he said. “As this continues to develop and is modified and enhanced as an application, hopefully it will approach a cost point similar to some of the other options and have a broader application. … My experience, given past history, is that the concept of using a patient’s own material and then enriching it is expensive.”

Thomas Mustoe, a plastic surgeon and professor of surgery at Northwestern Memorial Hospital, also expects laViv to be costly and expressed skepticism that it will necessarily work better than other nonsurgical options. He said the FDA approval indicates that the procedure is safe and can work, but patients should not necessarily conclude more.

“This is certainly significant that you have approval,” Mustoe said. “It is going to be simple to inject. But what is unknown is whether it is going to turn out to be better than other fillers. We’re still sorting out what is possible with a needle and an injection.”

Part of the reason for the popularity of injectables is the cost. Bull said they typically are no more than half the cost of surgery, which can run from $5,000 to $20,000, depending upon the areas of the face affected and technique used.

Few said some minimally invasive procedures can cost $3,000 or more. Botox is “a third or less of that,” he said, but needs to be redone every three to six months, while other products can last “on the order of years.” Plastic surgeons have been combining regimens to “get a result that is better than either (product) alone,” he said.

Susan P., 57, a Chicago resident and executive assistant who asked that her last name not be used, has been seeing Few for about four years. He has injected Botox and Restylane around her eyes, the sides of her nose and her forehead, and she estimates she spends about $3,500 per year.

“There’s no giveaway that I’m doing anything, which is really appreciated,” she said. “The longer you do this, the less often you have to go. There’s a cumulative effect.”

Agee estimates she spent a little less than $2,500 for a combination of Radiesse for her cheeks, Botox around her eyes and Juvederm for the sides of her nostrils. Though initially apprehensive about possible side effects, she said, she’s more than willing to repeat it.

“The process was a lot easier than what I anticipated,” she said. She had worried: “My God, what happens if I look like a freak? I work in public nine hours a day. I have like 50 employees under me. I’m going to look like Frankenstein.”

Mustoe said the key to avoiding such results is proper pacing of treatments and not overdoing it.

“Some patients look overly plumped up. There are limits to what you can do,” he said. “You only have to look at the folks in Hollywood to see that a series of (too many) small procedures can have a very strange effect.”

I Had a Facelift 4 Years Ago and Don’t Want Another One What Can I Do to Help Sagging?

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Sharla DeCelle in Las Vegas, NV asks:

I had a facelift approximately 4 years ago and have started to get the deep fowls around my mouth. I’m 60 years old and want to look vibrant for my age but do not want a another facelift. Are there other alternatives that will help the wrinkles and jowls?

Several options for nonsurgical facial rejuvenation:

If your areas of concern are the “deep frowns” around your mouth; so often the nasolabial folds and marionette lines around the mouth contribute to the sagging and contribute to the aged appearance.  Without doing “surgery”, injections into these areas, particularly with fat transfer or other materials can provide good resolution/good improvement, without undergoing a repeat facelift.  Specifically for wrinkles on the other hand; wrinkles are nicely treated with expert fractionated laser treatment.  If you are concerned about the sagging jowl; in some instances laser lipolysis can provide some tightening in this area although this has to be done with great expertise and care.

Nonetheless there are options to help rejuvenate the face that don’t entail or require facelift surgery.  But there is not a single procedure that will provide resolution for the areas you are concerned about, but a combination of these treatments can remedy the problem.

David Q. Santos, MD

Seattle Facial Plastic Surgeon

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FDA Okays First Autologous Filler for Smile Lines

Article  from here

 

The US Food and Drug Administration (FDA) late yesterday approved the first autologous aesthetic cell therapy to improve the appearance of moderate to severe nasolabial fold wrinkles in adults.

The product, azficel-T (laVív), is from Fibrocell Science, Inc, a company focused on developing personalized cell therapies for aesthetic, medical, and scientific applications.

According to the company, creating azficel-T involves a patented technology whereby fibroblasts are extracted from behind the patient’s ear and sent to the Fibrocell Science laboratory, where they are multiplied for about 3 months and then frozen until needed.

Azficel-T (laVív). Fibrocell Science Inc

Over a series of 3 treatment sessions, typically 3 to 6 weeks apart, they are injected into nasolabial folds to reduce the appearance of smile lines.

The company says the therapy will become available gradually through trained clinical investigators in select metropolitan areas. As manufacturing capacity is increased and more physicians trained, the number of cities served will expand as well.

The product will be mostly administered by dermatologists and plastic surgeons; only physicians who complete a Fibrocell-approved training program will be able to administer it.

The training program teaches proper biopsy collection and shipment procedures, treatment preparation and injection technique, and logistics tracking to ensure that the cells received by each patient are derived from that same patient.

“Revolutionary” Approach

“The concept of using a patient’s own collagen-making cells is a revolutionary way to help treat nasolabial fold wrinkles and help restore a fresh appearance,” Robert A. Weiss, MD, clinical associate professor, Johns Hopkins School of Medicine, Baltimore, and director of the Maryland Laser Skin and Vein Institute, Hunt Valley, noted in a company-issued statement.

“Since this is a biological process that works over time, [azficel-T] is able to provide gradual and natural-looking results,” noted Dr. Weiss, who participated in clinical trials of azficel-T.

A patient’s nasolabial fold wrinkles before (left) and after (right) azficel-T treatment. Fibrocell Science Inc

This approach is “likely appeal to patients who want to take a very new approach to treating wrinkles,” Stacy Smith, MD, associate clinical professor in the Division of Dermatology at the University of California–San Diego, who also worked on azficel-T clinical trials, said in a statement.

“By injecting tens of millions of the person’s own fibroblasts, patients now have the option to help smooth smile lines by adding cells to replace those that may have been lost through the aging process,” he added.

Babak Azizzadeh, MD, FACS, director of the Center for Advanced Facial Plastic Surgery and assistant clinical professor of facial plastic surgery at University of California–Los Angeles, commented, “It’s an interesting and novel approach that will generate some excitement among physicians and some patients.

“But at the end of the day,” he told Medscape Medical News, “it’s going to depend on whether the results are better than with off-the-shelf injectables, such as Juvederm (Allergan), Restylane (HA North American Sales AB), and Sculptra (Sanofi-Aventis), which are the main competition.”

Dr. Azizzadeh was not involved in the studies of azficel-T and has not treated any patients with it.

He added that “a limiting factor is that the patients have to have a biopsy and then wait 3 months before they get their injections, and then they have to go through a series of treatments. It’s a long process. Physician acceptability, with the length of time involved, may also be an issue.”

2 Pivotal Clinical Trials

The FDA approval was based largely on 2 identical phase 3 multicenter, randomized, double-blind, placebo-controlled studies involving 421 patients who underwent 3 treatment sessions approximately 5 weeks apart.

On the basis of investigators’ and patients’ assessments, a significantly greater proportion of patients demonstrated a positive response to treatment with azficel-T than with placebo, the company notes. The treatment improved the appearance of nasolabial fold wrinkles for the 6 months of patient follow-up after the last treatment. The company said studies are ongoing, looking at how long beyond 6 months after the last treatment the effect may last.

In clinical trials, azficel-T was well tolerated, according to the company. The most common adverse events were mild to moderate injection-site reactions that usually resolved within 1 week. As part of a postmarketing requirement, Fibrocell will set up a registry of approximately 2700 patients to further evaluate the safety of this autologous cell therapy.

TLC for Skin Below the Chin

Article from The American Society for Aesthetic Plastic Surgery

If you’re a woman of a certain age, a glance at your exposed chest may show that you need more than a pushup bra. Women in their fifties begin to show wear in exposed areas. According to the June 2011 issue of More magazine, “Your skin below the chin needs TLC.”

Nora Ephron, author of “I Feel Bad About My Neck” is not alone. Necks are frequently left unprotected with moisturizer and sunscreen. But, if you’re starting to look jowly, there’s a surprising and effective treatment for loose skin under the jawline. A plastic surgeon or dermatologist can skillfully inject Botox into the vertical muscles under your jaw, relaxing them so that they loosen their downward pull on the skin. Cost is $250 and up.

You may also have loose neck skin, sadly but aptly referred to as “turkey neck.” Tighten up before Thanksgiving with Thermage, a skin tightening treatment that uses radio-frequency energy to heat the skin’s deepest layers and stimulate collagenproduction. Cost is about $1,200. You can also boost Thermage effects with Fraxel, a resurfacing laser. If your knees are also sagging, the same skin tighteners used on the neck are also used to lift and tighten this hard-to-fix area.

Your chest, which is so evident in today’s scooped out styles, may be striated with lines and discolored with mottling. Mottling can be treated with glycolic peel laced with retinoic acid for about $100 to $200 a session. Pigment-targeting lasers will take care of your brown spots in about 3 sessions at $350 each. A hyaluronic acidfiller, such as Restylane, could even be used to plump up the lines in your chest for about $500 a treatment.

To prevent further damage, slather your chest with sunscreen, especially in the frequently-exposed clavicle area.

 

Celebrity Plastic Surgery:  Lynne Curtin from the Real Housewives

Lynne Curtin from The Real Housewives

How Can I Correct This Naseolabial Fold Problem on One Side of my Face?

 msmmi in sf in Pleasanton, CA asks:

2 months ago I had 4 qaud eye lift, brow lift, full facelift and lipo of the neck. I had some nasolabial folds before surgery, and the doctor assured me these procedures would correct the problem. However, the fold on one side is still there, and never seemed to get better. I feel the malar fat pad may not have been lifted as much as it should have been. I am not into fillers that don’t last, after spending all this money for a more lasting fix. what should be done?

Photo Courtesy of RealSelf.com

It is now two months after the procedure and there has been a number of procedures performed, including your eyelift and brow lift and facelift, liposuction and neck lift.  These are a lot of procedures and even though it has been two months there is still some reasonable amount of healing that needs to occur.  Most people desire resolution of all their swelling and healing problems by a week or a month, but essentially three and six months or more is required.

Therefore assessing the nasolabial folds is somewhat premature at this phase, but a number of things can be discussed at this time.  Facelift procedures can soften the nasolabial folds, but rarely get rid of the significant concerns of the nasolabial folds.  Fillers are the best answer.  There are a number of fillers; the temporary ones are beneficial.  If you are interested in a “lasting fix” then more permanent type fillers are helpful, including Artifill and Sculptra, as well as fat grafting.  Fat grafting tends to be the best answer in many instances due to its reliability and the fact that it comes from your own body to begin with.

So the best answer to your question is to wait a little bit of time, at least three months if not six months, and assess things and consider fillers after that period of time.  Fat grafting would be my first option, Sculptra would be a second answer.

David Q. Santos, MD

Seattle Facial Plastic Surgeon

Cell-enriched fat grafting-future possibilities

 ”Cell-enriched fat injections” or fat grafting is a new technique that shows some promise. 

Today’s traditional fat-grafting techniques are quite successful as they provide a more permanent option  for facial rejuvenation when compared to the traditional well known filler technique applications such as juvederm(r), restylane(r), and radiesse(r).  However, one of the down sides of fat-grafting is that often, only 30% of cells transplanted survive.  This still is a reasonable success rate but obviously there is needed room for improvement.

“Cell-enriched fat grafting” enters this niche to try to improve on the grafting take.  The enrichment of an individual patient’s own fat with stem regenerative cells can provide potential significant enhancement of success and efficiency for facial filler rejuvenation.  Fat is taken from the patient’s stomach primarily, but can also be obtained from thighs, and flank.  Regenerative and stem cells are taken from the fat and concentrated, and these  extracted cells are then combined with some of the patient’s own fat tissue, which forms a cell-enriched fat graft that is subsequently injected into the specific area of concern.

There is future promise for stem cell grafting for patients in the US; this is a promising technology as theoretically, more concentrated regenerative stem cells are superior in efficacy to concentrated fat due to the greater concentration.  We know from past experience over the last 2 decades, that the more concentrated the fat for fat grafting, the better success.  Now additional engineering on this important cosmetic use is on the horizon.

Nonetheless, as always with new technologies, caution is suggested.  There are many kinks to unravel as the studies become more available. 

Cytori therapeutics (www.cytori.com, CYTX), recently  received additional patents which involve the preparation of adipose-derived stem and regenerative cells.  Cytori is a leading medical technology company, that is focused on achieving full potential of adult regenerative cells from adipose tissue applications. 

Dr. David Santos- FacialBeauty.com

Is it possible to make my smile not as wide?

Photo courtesy of smileplus.wordpress.com

Jonass in Dallas asks:

“Hi I am 20 years old, when I smile or laugh my mouth opens very wide so it seems that my smiel goes from ear to ear! is there anyway to fix it so when I’m laughing, my mouth won’t open as much?”

This is a significantly delicate and tricky proposed concern.  Overall there is not a recommended surgical procedure.  However, based on your anatomy there is a possibility that some expertly placed small degree of Botox can diminish some of the widening of the smile.  However, nonetheless this has to be done, performed and assessed by a physician who does a significant amount of Botox treatments.  Overall, I think that it is important to get a good opinion from a physician as to whether anything, if at all, should be done.  Try to trust the opinion of the physician that you consult with and if you have a trustworthy physician and a physician who is well recommended and if this physician says don’t have any procedures done then importantly you should listen to this recommendation.

David Q. Santos, MD

Seattle Facial Plastic Surgeon

Is It Safe to Have a Facelift After Sculptra?

Eimel in Gold Coast asks:

“I had a Sculptra injection and am supposed to have 1 more in 6 weeks, the doctor’s idea was to make my skin stronger so he can do a threadlift. After doing some research I think this is not for me and I’d like to go back to my original idea of having a traditional facelift – but I am now worried that if I get a facelift when my skin is a bit tighter from the Sculptra treatment it will sag again in 1-2 years once the Sculptra wears off. Can this be a problem after just 1 Sculptra injection?”

It is safe to have a facelift after Sculptra.

Sculptra is a quite successful filling agent that provides fullness to the face and lasts for a prolonged period of time.  Some feel two years and some researchers and physicians feel that it lasts even longer.  It is actually difficult to absolutely state the time that an individual Sculptra might dissipate, if at all.  It does not simply go away completely at two years.

The best time to choose to do a facelift should not be influenced by when fillers such as Sculptra might wear off.  When there are significant sagging components to the face, particularly jowls and neck area, the best remedy is for a facelift.  Indeed many individuals undergo a facelift and also have concomitant filling, whether fat grafting, Sculptra or other fillers such as Restylane.  This provides additional rejuvenation.  If you have a facelift now, there will be changes over time that are for the most part unpredictable.

The best answer is to have a facelift now and as time goes along consider supplemental rejuvenation treatments as needed and as recommended by your physician, such as additional Sculptra or additional other fillers.  On the other hand, if you wait for the Sculptra end point, when all the Sculptra is dissipated, the time period of this waiting period could be two years, could be several years and is unpredictable.

By David Q. Santos, MD -Real Plastic Surgery

Lower Eyelids Look “Sad” After Weight Loss

DeLa in aucune asks:

“Hello, sometimes when i have a bad period, i loss face’s weight, and I make my eyes more sad. My lower eyelids are more “falling”. When I will regain face’s fat it will return as before? I don’t have strong cheekbones, so it’s loss forever (I’m 19) i have to go to see a plastic surgeon for fat injection?”

Fillers for lower eyelids. At a young age of 19 the best long-term picture is to keep healthy and keep your weight at an optimum level. The face does of course change with weight gain and weight loss and this is even more true in our 40s and beyond. Nonetheless fillers are likely the best answer for the tired appearance and I would encourage just a small amount of injectable initially and increase as time goes on. Start off with Restylane or Juvéderm and see how this works for you over the subsequent six to nine months or even a year. Not always does filler provide the satisfaction that you are seeking and reasonable expectations are important and this can be discussed with your plastic surgeon. More permanent options in the future include fat injections if you are properly motivated and generally reasonably high success is achieved in expert hands. – David Santos MD, FACS

 

Would a Lower Lift Help with Sagging in the Marionette Area?

Marionette Area

Katt122 in Florida   asks:

“Would a Lower Lift Help with Sagging in the Marionette Area?  Due to 30lb weight loss I have sagging in the marionette line area. Its not too bad but it bothers me that I look sad. I talked to a plastic surgeon about a lower lift. He said this would also help my jaw line. What would this entail. Is the recuperation difficult. I am 48. Would juvederm help to hold off the surgery for awhile? Can it help the neck? I have already had my eyes done and rhinoplasty so surgery isn’t new to me.”

Combination treatment facelift plus filler is best answer for sagging marionette lines. The marionette area sometimes is reasonably simple to treat, but other times is more difficult. A simple answer is to utilize simple, safe and less expensive techniques such as Juvéderm or Restylane for the marionette line area. This can be a potential six to nine month or even one year successful therapy in many instances, but not all. More permanent answer entails Sculptra or lipo injection to the area that can additionally soften the marionette line. These answers are safe and less expensive. Nonetheless a facelift provides an excellent improvement in marionette lines in most instances, but there are some instances where supplemental injection is needed. So at 48 years of age I would suggest trying fillers first and if this doesn’t resolve things to your satisfaction then strongly consider a mini-lift or facelift by an expert surgeon in the area who has done a lot of facelift procedures. And again even then, consider subsequent injections if this is not satisfactory. – Dr. Santos MD, FACS

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